Cheap Flights from Knoxville to St. Louis

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Cheap TYS to St. Louis flights

Book your TYS to STL flights with Expedia and find last-minute Knoxville to St. Louis airfare. Expedia offers discount airfare on multiple airline carriers that fly direct and indirect routes between TYS and STL, with new flight deals and promotions almost daily. When you book your next trip from McGhee Tyson to Lambert St. Louis Intl. with Expedia, you can rest assured you’re getting great ticket prices and excellent service from one of the world’s most trusted travel providers.

TYS to STL Flight Schedule

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Popular Flights from Knoxville, Tennessee

Browse popular flight destinations from Knoxville (TYS), and plan your next exciting trip. Expedia has cheap flights from Knoxville on multiple airline carriers, so book your next trip today!

Popular Flights from St. Louis, Missouri

Browse popular flight destinations from St. Louis (STL), and plan your next exciting trip. Expedia has cheap flights from St. Louis on multiple airline carriers, so book your next trip today!

TYS to STL Route Map


Interesting Facts About Flights from Knoxville to St. Louis (TYS to STL)

  • American Connection operated flights from TYS to STL using one type of aircraft in 2009.
  • The newest aircraft servicing TYS to STL in 2009 was American Connection's EMB-145 from Embraer. The EMB-145 started flying in 1996.
  • The oldest aircraft servicing trips from Knoxville, TN to St. Louis, MO in 2009 was American Connection's EMB-145 from Embraer which started flying in 1996.
  • The smallest aircraft servicing flights from TYS to STL for American Connection is the EMB-145 built by Embraer with 50 seats.
  • The largest aircraft servicing flights between Knoxville and St. Louis from American Connection is the EMB-145 built by Embraer with 50 seats.

(Source: FAA & BTS 2009 Databases)